Despite their awesome power, Destroyers are not invincible. Throughout the course of Mass Effect 3, Commander Shepard and his crew manage to kill four Destroyers. The first Destroyer they defeat on the Krogan homeworld of Tuchanka by summoning a gigantic Thresher Maw, which tackles the Destroyer and drags it down beneath the desert, burying it. A second Destroyer is killed on the Quarian homeworld of Rannoch, which Shepard tags with a satellite targetting device, allowing the Quarian flotilla in orbit to bombard the Reaper with full firepower. The Reaper is mortally damaged and speaks to Shepard before it finally shuts down, telling him that his efforts to break the Reapers' cycle of genocide are doomed to failure. During the Battle of London, Shepard blows up a Destroyer mounting a Hades Cannon using a Cain "Nuke Launcher", and destroys another using two Thanix missile batteries.